Metabolism of retinoids by embryonal carcinoma cells.
نویسندگان
چکیده
منابع مشابه
Metabolism of retinoids by embryonal carcinoma cells.
Several embryonal carcinoma (EC) cell lines were tested in culture for their ability to metabolize all-trans-[3H]retinol, all-trans-[3H]retinyl acetate, and all-trans-[3H]retinoic acid. There was little, if any, metabolism of all-trans-retinol to more polar compounds; we failed to detect conversion to acidic retinoids by reverse-phase high performance liquid chromatography and derivatization. W...
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Murine embryonal carcinoma (EC) cells were characterized with respect to their ability to metabolize the polycyclic aromatic hydrocarbon, benzo(a)pyrene [B(a)P]. The extent of metabolic activation varied more than 100-fold among the teratocarcinoma-derived cell lines examined. This difference in metabolic activity was correlated with an increase in the formation of specific metabolites that wer...
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The key role of vitamin A in embryonal development is reviewed. Special emphasis is given to the physiological action of retinoids, as evident from the retinoid ligand knockout models. Retinoid metabolism in embryonic tissues and teratogenic consequences of retinoid administration at high doses are presented. Physiological and pharmacological actions of retinoids are outlined and explained on t...
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Murine embryonal carcinoma (EC) cells were characterized with respect to their ability to metabolize the polycyclic aro matic hydrocarbon, benzo(a)pyrene [B(a)P]. The extent of met abolic activation varied more than 100-fold among the teratocarcinoma-derived cell lines examined. This difference in met abolic activity was correlated with an increase in the formation of specific metabolites that ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1985
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(17)39270-0